Cystic Fibrosis-Related Diabetes: The presence of microvascular diabetes complications

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Cystic fibrosis-related diabetes: the presence of microvascular diabetes complications.

OBJECTIVE Cystic fibrosis (CF)-related diabetes has been regarded as a mild form of diabetes with a low risk of severe diabetes complications. The prevalence of CF-related diabetes increases with age, resulting in a 50% prevalence of diabetes at age 30 years. We sought to investigate whether microvascular complications in CF-related diabetes appear with a relevant frequency. RESEARCH DESIGN A...

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Microvascular complications in cystic fibrosis-related diabetes.

OBJECTIVE The incidence of cystic fibrosis-related diabetes (CFRD) and the prevalence of diabetic microvascular complications were determined at the University of Minnesota. RESEARCH DESIGN AND METHODS Cystic fibrosis patients have undergone annual oral glucose tolerance testing since 1990. Database review was performed to determine diabetes duration and the results of annual urine albumin-to...

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Cystic fibrosis related diabetes.

Diabetes is a frequent complication seen in cystic fibrosis patients as they reach adulthood. Cystic fibrosis related diabetes (CFRD) is distinguished as a separate entity with features that include progressive loss of islet beta cell mass and insulin deficiency, as well as insulin resistance. Abnormalities in glucose tolerance may be detectable for many years prior to the development of overt ...

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Cystic Fibrosis Related Diabetes

Diabetes mellitus and glucose intolerance are common in adolescent and adult patients with CF (Lanng et al, 1995; Moran et al, 1998). The prevalence of CF related diabetes (CFRD) increases with age (Moran et al, 1998) and in patients over 20 years of age may be as high as 53% (Lanng et al, 1995). CFRD occurs in up to 30% of individuals by the age of 25 and is invariably associated with pancreat...

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Cystic Fibrosis-Related Diabetes

Cystic fibrosis (CF) is the most common autosomal recessive disorder in Caucasian populations. Individuals with CF have seen significant increases in life expectancy in the last 60 years. As a result, previously rare complications are now coming to light. The most common of these is cystic fibrosis-related diabetes (CFRD), which affects 40-50% of CF adults. CFRD significantly impacts the pulmon...

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ژورنال

عنوان ژورنال: Diabetes Care

سال: 2006

ISSN: 0149-5992,1935-5548

DOI: 10.2337/dc06-0654